New DNA compounds could help treat lupus
New DNA compounds could help treat lupus
- IOWA CITY, Iowa - A U.S. research team led by the University of Iowa says it has created DNA-like compounds that inhibit the cells responsible for developing lupus. Using human cell lines and isolated mouse cells, Dr. Petar Lenert, an assis- tant professor of internal medicine at the University of Iowa, said he and his colleagues showed the DNA-like com- pounds were able to selectively reduce the activity of two types of immune cells called autoreactive B cells and den- dritic cells. When given to mice with lupus, the compounds delayed death and reduced kidney damage, proving their effectiveness. "With further testing, we hope that class R inhibitory oligonucleotides may become another weapon in the fight against lupus," Lenert said in a release. The study, which included researchers at the Boston University School of Medicine, is reported in the journal Arthritis Research and Therapy.
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